Gene information
Official symbol CTLA4
Official full name cytotoxic T-lymphocyte associated protein 4
Gene type protein-coding gene
Chromosome2q33.2
Alias symbolCD152; CD; GSE; CTLA-4
Previous symbolCELIAC3; IDDM12
Gene familyCD molecules; V-set domain containing
Resources
Entrez Gene 1493
HGNC HGNC:2505
Ensembl ENSG00000163599
Vega OTTHUMG00000132877
UCSC uc002vak.3
GO terms: 34 records
GO Description Category LogP Number of genes Detail
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002764 immune response-regulating signaling pathway GO Biological Processes -3.80325753 14 More
GO:0006974 cellular response to DNA damage stimulus GO Biological Processes -1.56334957 15 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030135 coated vesicle GO Cellular Components -4.65185370 14 More
GO:0030136 clathrin-coated vesicle GO Cellular Components -3.00394155 9 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0032945 negative regulation of mononuclear cell proliferation GO Biological Processes -3.06905273 11 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0045334 clathrin-coated endocytic vesicle GO Cellular Components -4.88495680 8 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045581 negative regulation of T cell differentiation GO Biological Processes -3.22341771 8 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045620 negative regulation of lymphocyte differentiation GO Biological Processes -5.62617381 12 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0050672 negative regulation of lymphocyte proliferation GO Biological Processes -2.56497893 10 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050868 negative regulation of T cell activation GO Biological Processes -5.59075646 10 More
GO:0050869 negative regulation of B cell activation GO Biological Processes -2.50832748 6 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0070664 negative regulation of leukocyte proliferation GO Biological Processes -3.96184640 13 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:1902106 negative regulation of leukocyte differentiation GO Biological Processes -7.27922558 19 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903707 negative regulation of hemopoiesis GO Biological Processes -7.72888419 20 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04660 T cell receptor signaling pathway KEGG Pathway -4.46130434 8 More
hsa05320 Autoimmune thyroid disease KEGG Pathway -5.52369866 7 More
Drug-Gene interaction
view
Related drugs: 18 records
Drug name Interaction type Source PMID View
abatacept NCI 9758890 view
alcohol NCI 11025487 view
antibiotic NCI 10030847 view
atezolizumab CIViC 25428504 view
bleomycin NCI 11489978 view
bortezomib PharmGKB 21228734 view
cyclosporine PharmGKB 18021981 view
dexamethasone PharmGKB 21228734 view
ipilimumab inhibitorantibody TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsCancerCommonsTTD 18049334 view
melphalan PharmGKB 21228734 view
methimazole NCI 15504312 view
prednisone PharmGKB 21228734 view
sirolimus NCI 798290711698435 view
tacrolimus PharmGKB view
thalidomide NCI 10823791 view
tremelimumab inhibitorantibody TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsTTD view
wortmannin NCI 10464177 view
zalifrelimab TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_005214.5:c.49A>G genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Yip HK et al. Circ J. 2007
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